SEGLUROMET® Uses and advantages

SEGLUROMET® is a combination medication developed by Merck & Co. that pairs two active ingredients, ertugliflozin and metformin, to manage type 2 diabetes effectively. Here we will provide its formulation, uses, advantages, side effects, dosage, precautionary measures, company information, year of invention, and pricing in the UK and USA.

Formulation of SEGLUROMET®

SEGLUROMET® is available in tablet form for oral administration. Each tablet contains:

• Active Ingredients:
  • Ertugliflozin: A sodium-glucose cotransporter 2 (SGLT2) inhibitor.
  • Metformin: An oral biguanide antihyperglycemic agent.
• Excipients: These include various inactive ingredients that aid in tablet formation and stability.

Uses of SEGLUROMET®

SEGLUROMET® is indicated for:

• Management of Type 2 Diabetes Mellitus: It is used in conjunction with diet and exercise to improve blood sugar control in adults.

The combination of ertugliflozin and metformin addresses different aspects of diabetes management, making it a versatile treatment option.

Advantages of SEGLUROMET®

1. Dual Mechanism of Action: The SGLT2 inhibition helps reduce glucose reabsorption in the kidneys, while metformin improves insulin sensitivity and decreases hepatic glucose production.
2. Weight Loss Benefits: Many patients experience modest weight loss, which can be beneficial for those with type 2 diabetes.
3. Cardiovascular Benefits: Evidence suggests that SGLT2 inhibitors may have cardiovascular protective effects.
4. Convenience: A single tablet combining two medications simplifies the treatment regimen for patients.

Side Effects of SEGLUROMET®

While SEGLUROMET® is generally well-tolerated, potential side effects include:

• Common Side Effects:
  • Nausea
  • Diarrhea
  • Upper respiratory tract infections
  • Genital mycotic infections
• Serious Side Effects:
  • Ketoacidosis (though rare)
  • Acute kidney injury
  • Hypoglycemia (especially if used with other glucose-lowering agents)

Dosage of SEGLUROMET®

The typical dosing regimen for SEGLUROMET® is as follows:

• Initial Dose: The starting dose is often individualized based on the patient’s current medications and glycemic control.
• Maintenance Dose: Usually ranges from 1,000 mg to 2,000 mg of metformin combined with 5 mg or 15 mg of ertugliflozin, taken once daily.

Adjustments may be necessary based on the patient’s response and tolerability.

Precautionary Measures of SEGLUROMET®

Before starting SEGLUROMET®, healthcare providers should consider:

• Renal Function: Assess renal function prior to initiation and periodically thereafter, as both components can affect kidney health.
• History of Diabetic Ketoacidosis: Screen for a history of ketoacidosis or other metabolic disorders.
• Drug Interactions: Review current medications to avoid potential interactions, especially with other antidiabetic agents.
• Pregnancy and Lactation: Discuss risks and benefits with women who are pregnant or breastfeeding.

Year of Invention of SEGLUROMET®

SEGLUROMET® was approved for use in 2019. Its introduction marked an important advancement in the treatment landscape for type 2 diabetes, particularly for patients requiring dual therapy.

Company Information of SEGLUROMET®

Merck & Co., Inc. is a global leader in healthcare and pharmaceutical innovation, founded in 1891. The company is dedicated to advancing medical science and improving patient outcomes through research, development, and the provision of life-saving medications

Price in USA and UK of SEGLUROMET®

The cost of SEGLUROMET® varies based on location and healthcare policies:

• USA: The average retail price is approximately $600 for a 30-day supply, depending on the dosage.
• UK: The price is around £500 for a month’s supply, but this can vary based on the pharmacy and any available discounts.

Conclusion

SEGLUROMET® (ertugliflozin and metformin) represents a significant advancement in the management of type 2 diabetes. Its dual-action formulation provides a comprehensive approach to glycemic control, with additional benefits such as weight loss and potential cardiovascular protection. As with any medication, it is essential for patients to work closely with their healthcare providers to ensure safe and effective treatment.